A case of autoimmune cholangitis with autoimmune thrombocytopenic purpura.

Autoimmune thrombocytopenic purpura.

Adult autoimmune throbocytopenic purpura (ATP) is a platelet disorder that develops in certain individuals with a genetic as well as sex (female) predisposition following an environment event (?viral). This results in the production of an IgG antiplatelet antibody capable of reacting with the host's platelets, as well as crossing the placenta. This leads to the rapid clearance and destruction o...

Autoimmune Hepatitis Associated with Immune Thrombocytopenic Purpura

Although autoimmune hepatitis (AIH) is frequently complicated with chronic thyroiditis or other autoimmune disorders, reports on its association with immune thrombocytopenic purpura (ITP) are scarce. We herein describe a case of AIH associated with ITP. A 75-year-old Japanese woman was admitted to our hospital due to increased aminotransferase levels and severe thrombocytopenia. Elevated serum ...

Immune pathophysiology of autoimmune thrombocytopenic purpura.

Chronic autoimmune thrombocytopenic purpura (AITP) is an immune-mediated, bleeding disorder in which platelets are opsonized by autoantibodies and prematurely destroyed by phagocytic cells in the reticuloendothelial system. It is classed as an organ-specific autoimmune disease primarily mediated by immunoglobulin G (IgG) autoantibodies and its etiology appears to be similar to that observed for...

Vincristine-loaded platelets for autoimmune thrombocytopenic purpura.

Autoimmune cholangitis – a clinical case

The authors present the case of a previously healthy, asymptomatic 45 year old female patient, who was referred to the Internal Medicine service for study of elevated hepatic enzyme levels (alkaline phosphatase, gamma-glutamyl transferase and amino transferases) diagnosed in routine laboratory tests. The patient did not present any alterations in the objective examination and further study reve...